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KMID : 0378119800070010064
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Chungnam Medical Journal
1980 Volume.7 No. 1 p.64 ~ p.68
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Effet of Surgery under General Anesthesia(Halothane) on Renal Function
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Abstract
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As an attempt to elucidate the functional change of human kidney by surgery under general anesthesia(halothane), various renal functions were compared before, during and after surgery under anesthesia among 18 adult patients admitted at Chungnam National University Hospital. They were confirmed to have normal functions before surgery (control group). Most of renal functional changes recovered 3 days after surgery.
The results of renal functional changes during surgery under anesthesia were summarized as follows;
1) decreased renal plasma flow(CPAH) as 70. 8% with P<0. 01
decreased glomerular filtration rate(CIN) as 78. 6% with P<0.05
decreased urine flow as 36. 0% with P<0. 01
slight elevation of filtration fraction without significance
2) decreased osmolar clearance (Cosm) with P<0. 01
Most cases(15/18) of negative fluid balance by free water clearance
3) decreased urinary filtration and excretion of Na+ with P<0.05
slight elevation of renal tubular reabsorption rate without significance
extraordinally increased filtration of K+ with P<0.01From the above results, it is suggested that the effect of surgery under halothane anesthesia on renal function is due to renal hemodynamic change by increased compensatory renal vascular resistance during anesthesia and surgery.
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